Expression of C-reactive protein in children with acute otitis media and its significance

Abstract

Objective To analyze the expression of C-reactive protein(CRP) in 2-12-year-old children with acute otitis media(AOM), we can use CRP as a strong evidence for the usage of antibiotics in the diagnosis and treatment of otitis media. Methods 250 children with AOM were selected as the research subjects.52 cases refused to test, CRP was detected in 198 children (231 ears). CRP was examined in all patients before treatment, they were followed up for 1 month.After treatment, CRP was reviewed in three days, one week and one month, respectively. Results In 198 children (231 ears), 71 ears were recovered, 33 ears improved, and 127 ears were ineffective in three days, the effective rate was 45.0%(104/231).100 ears were recovered, 45 ears improved, and 86 ears were ineffective in one week, the effective rate was 62.8%(145/231).121 ears were recovered, 56 ears improved, and 54 ears were ineffective in one month, the effective rate was 76.6%(177/231). The effective rate were significantly different among the three groops (χ2=14.643、48.406, 10.494, all P<0.05). Among 198 children, 188 ears were in the low expression group, 43 ears were in the high expression group.After three days of treatment, the composition ratio of group B and group C was changed(χ2 =5.979, P=0.014), while group A had a significant change(χ2 =13.948, P=0.000). Therefore, early use of antibiotics was effective in reducing CRP, so as to reduce the clinical symptoms in children. Conclusion CRP can be used to guide antibiotic monitoring. Key words: C-reactive protein; Otitis media; Child