Expression and significance of mismatch repair protein 1, mismatch repair protein 2 and cellular adhesive molecular variants in ovarian epithelial carcinoma

Abstract

Objective To explore the expression and clinical significance of human mismatch repair protein1(MLH1), mismatch repair protein2(MSH2) and cellular adhesion molecular variants(CD44v6) in ovarian epithelial carcinoma. Methods The immunohistochemical S-P method was used to detect the expression levels of MLH1, MSH2 and CD44v6 in 60 cases of ovarian epithelial carcinoma, 35 cases of borderline ovarian tumor and 35 cases of ovarian benign tumor tissue. Results The positive expression rates of MLH1 in ovarian epithelial carcinoma and boundary tumor were 43.33%(26/60), 48.57%(17/35), which were significantly lower than 91.43%(32/35) of benign tumor (χ2=20.16, 15.31, all P 0.05). The decreased expression of MSH2 was closely related to the differentiation degree of ovarian epithelial carcinoma, lymph node metastasis and clinical stage (χ2=5.22, 7.86, 4.38, all P<0.05). The positive expression rates of CD44v6 in ovarian epithelial carcinoma tumors, boundary tumors and benign tumors were 78.33%(47/60), 54.29%(19/35), 17.14%(6/35), the differences were statistically significant (χ2=33.55, 10.52, all P<0.05). CD44v6 was closely related to lymph node metastasis of ovarian epithelial carcinoma and clinical stage (χ2=6.10, 5.88, all P<0.05). Conclusion MLH1, MSH2 and CD44v6 play important roles in the occurrence and development of ovarian epithelial carcinoma, and are important reference index to judge prognosis. Key words: Ovarian neoplasms; Epithelium; Muts DNA mismatch-binding protein; Cell adhesion molecules variants; Ovarian epithelial carcinoma; Immunochemistry