Expression and significance of KAI1/CD82, E-cadherin and 15-catenin in endometrial carcinoma

Abstract

Objective To explore the expression of KAI1/CD82,E-cadherin and β-catenin in endometrial carcinoma,and to investigate their correlations to clinicopathological parameters of endometrial carcinoma. Methods The expressions of KAI1/CD82,E-cadherin and β-catenin in 76 specimens of endometrial carcinoma,15 specimens of atypical endometrial hyperplasia and 20 specimens of proliferative endometrium were examined by immunohistochemical envision technique.Their correlations to clinicopathological parameters of endometrial carcinoma were statistically analyzed. Results Compare to normal proliferative phase endometrium and atypical endometrial hyperplasia,the expression of KAI1/CD82 in endometrial carcinoma was significantly decreased（P 〈0.01）,the abnormal expression of E-cadherin and β-catenin in endometrial carcinoma were significantly higher（all P 〈0.01）.In endometrial carcinoma,the expression of KAI1/CD82 was negative correlated with histological grade and depth of myometrial invasion（P 〈0.01,P 〈0.05）; The abnormal expression of the E-cadherin is related to histological grade and type（P 〈0.01,P〈0.05）; The abnormal expression of β-catenin was positively correlated with histological grade and FIGO stage（P 〈0.01 ,P 〈0.05）.The down-regulation expression of KAI1/CD82 was closely associated with the abnormal expression of E-cadherin and beta-catenin in endometrial carcinoma（P 〈0.01,P 〈0.05）. Conclusion The down-regulation of KAI1/CD82 and the aberrant expression of E-cadherin and β-catenin could be involved in the development of endometrial carcinoma.The loss or reduced expression of KAI1/CD82 was closely associated with the abnormal expression of E-cadherin and β-catenin in endometrial carcinoma. Key words: KAI1/CD82; E-cadherin; β-catenin; Immunohistochemistry; Endometrial neoplasms