Expression and clinical significance of serum vasohibin-1 in type 2 diabetes mellitus patients

F H Cheng

doi:10.3760/cma.j.issn.1008-6315.2019.02.010

F H Cheng

https://doi.org/10.3760/cma.j.issn.1008-6315.2019.02.010

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Objective To investigate the expression and clinical significance of vasohibin-1 (VASH-1) in patients with type 2 diabetes mellitus. Methods From November 2015 to December 2017, four hundred and twenty-two patients with T2DM in Chaoyang Central Hospital were selected and divided into three groups according to the urinary albumin excretion rate (UACR): normal albuminuria group ( UACR 300 mg / g, 130 cases). Three hundred healthy subjects in Chaoyang Central Hospital during the same period were selected as control group.The levels of serum VASH-1 and transforming growth factor -β1(TGF-β1) in each group were determined by enzyme linked immunosorbent assay. Results VASH-1 and TGF-β1 in diabetic group and control group were (579±236) ng/L, (350±141) ng/L and (18.92±2.21) μg/L, (5.69±0.70) μg/L, respectively.There were significant differences between the two groups (t=4.721, 6.142, P<0.01). The serum VASH-1 levels in normal albuminuria group, microalbuminuria group and massive albuminuria group were (450+ 182) ng/L, (571±194) ng/L, (786±201) ng/L, and the serum TGF-β1 levels were (11.71±1.81) μg/L, (14.02±2.91) μg/L, (19.32±1.97) μg/L, respectively.Compared with the normal albuminuria group, the serum VASH-1 and TGF-β1 levels in the microalbuminuria group and the massive albuminuria group were significantly higher (P<0.05), and the serum VASH-1 and TGF-β1 levels in the massive albuminuria group were significantly higher than those in the microalbuminuria group, with significant difference between the two groups (P<0.05). Multivariate linear regression analysis showed that serum VASH-1 level was positively correlated with TGF-β1 in diabetic patients (r=0.554, P=0.000). Conclusion With the progress of DN microangiopathy, the serum VASH-1 concentration in type 2 diabetes mellitus increased significantly through negative feedback to regulate and control the formation of neovascularization and delay renal interstitial fibrosis, so as to achieve the protection of the kidney. Key words: Type 2 diabetes mellitus; Diabetic nephropathy; Angiogenesis inhibitory protein 1; Transforming growth factor β1; Urinary albumin excretion rate; Enzyme-linked immunosorbent assay

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