Abstract
Objective To explore the changes of interleukin-33 in serum of patients with chronic severe hepatitis B. Methods 25 patients with mild chronic hepatitis B(MCHB group) and 25 patients with severe chronic hepatitis B(SCHB group) were collected. 18 healthy people were collected as control(HC group). ELISA method was used to detect IL-33 level in peripheral blood. Results The IL-33 levels in MCHB and SCHB group were(11.7±6.9)ng/L and (16.5±9.1)ng/L, respectively, which were significantly higher than(5.1±2.9)ng/L in HC group(t=4.037, 5.434, P=0.000, 0.000). The IL-33 level in MCHB group was lower than that in SCHB group(t=2.108, P=0.040). The IL-33 level was positively correlated with ALT, AST and HBV DNA(r=0.526, 0.568, 0.285, P=0.000, 0.000, 0.045). Conclusion IL-33 is involved in the pathogenesis of hepatitis B. IL-33 plays an important role in HBV-relate injury. Key words: Hepatitis B; Interleukin
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