Expression and clinical significance of KIF5A in triple negative breast cancer

Abstract

Objective To investigate the expression and clinical significance of KIF5A in triple negative breast cancer tissues. Methods The clinical and pathological data of 82 patients with triple negative breast cancer who underwent breast cancer resection were retrospectively analyzed. The expression of KIF5A in cancer tissues and corresponding adjacent tissues was detected by immunohistochemistry method, and its relationship with clinicopathological features was analyzed. Results The positive high expression rate of KIF5A in triple negative breast cancer tissues was 63.4%, but low or no expression in adjacent tissues. The abnormal expression of KIF5A was correlated with the TNM stage and Lymph node metastasis (all P 0.05). Survival analysis indicated that patients with high KIF5A expression in triple negative breast cancer were significantly shorter than those with low KIF5A expression(P<0.05). Conclusions The abnormally high expression of KIF5A in triple negative breast cancer tissues is associated with high TNM and lymph node metastasis in breast cancer, and high expression of KIF5A suggests that patients with triple negative breast cancer may have poor prognosis. Key words: Triple negative breast cancer; Immunohistochemistry; KIF5A; TNM stage; Lymph node metastasis