Expression and clinical significance of inflammatory factors IL-l beta and IL-13 in ulcerative colitis

Abstract

Objective To investigate the expression and clinical significance of inflammatory factors IL-l beta and IL-13 in ulcerative colitis. Methods From January 2016 to December 2016, 120 patients with ulcerative colitis in the Fourth People's Hospital of Liaocheng were selected as observation group.During the same period, 120 healthy volunteers were selected as control group.The serum levels of IL-l and IL-13 were detected by ELLSA method in the two groups. Results The serum IL-l level in the observation group was (192.3±23.6)ng/L, which was significantly higher than (169.8±20.3)ng/L in the control group (t=8.234, P=0.025). The serum level of IL-13 in the observation group was (869.5±56.8)ng/L, which was significantly lower than (893.2±52.1)ng/L in the control group (t=5.957, P=0.036). In the observation group, the serum IL-l level in the severe patients was (159.8±21.6)ng/L, which was significantly higher than that in the mild and moderate patients (F=16.931, P=0.018). In the observation group, the serum IL-13 level in the severe patients was (1 132.5±142.3)ng/L, which was significantly lower than that in the mild and moderate patients (F=15.049, P=0.022). Pearson correlation analysis showed that the level of serum IL-l beta and IL-13 in the observation group was negatively correlated (r=-0.547, P=0.036). Conclusion The serum IL-l beta and IL-13 levels in peptic ulcer patients with different severity has different degrees of expression, which can be used as the detection index of patients with peptic ulcer, and can provide the basis for clinical diagnosis of peptic ulcer. Key words: Colitis, ulcerative; Interleukin-1beta; Interleukin-13