Abstract
Abstract The anthelmintic dinitroaniline oryzalin interferes with the formation of microtubules and inhibits meiosis and mitosis in nematodes. Exposure to oryzalin resulted in deterioration in morphology of the oocytes and loss of synaptonemal complexes at meiotic prophase I. The nuclear matrix and envelope were poorly formed, and the central rachis was diminished. These results provide the basis for the loss of fecundity after treatment with the oryzalin resulting in control of parasitic nematodes.
Highlights
Oryzalin is a dinitrosulfonamide anthelmintic, which has been used as an herbicide since it interferes with plant cells by interrupting meiosis and mitosis (Morejohn et al, 1987)
The free-living nematode Caenorhabditis elegans was exposed to oryzalin and used as a biological model to characterize changes associated with such exposure
The result of this substitution is that it links the growth of C. elegans to its ability to metabolize the oryzalin in the medium, since it is the only sterol source available for nutrition
Summary
Oryzalin is a dinitrosulfonamide anthelmintic, which has been used as an herbicide since it interferes with plant cells by interrupting meiosis and mitosis (Morejohn et al, 1987). The free-living nematode Caenorhabditis elegans was exposed to oryzalin and used as a biological model to characterize changes associated with such exposure. This nematode is ubiquitous and is found in virtually all types of environments, including marine. Males arise from gametes that have been produced after X-chromosome nondisjunction; the two sexes experience an unequal number of X chromosomes, similar to humans.
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