Abstract
Abstract Albendazole, a benzimidazole anthelmintic, interferes with the formation of microtubules and inhibits meiosis in the nematode Ascaris lumbricoides var. suum. Pigs treated with albendazole had worms in their uteri that had a severely deteriorated central rachis, complete loss of synaptonemal complexes and irregular oocytes at meiotic prophase I. The nuclear matrix and envelope were poorly formed and there was formation of accessory nuclei. This study represents the first examination of the changes in meiotic nuclear architecture and meiotic chromosomes after exposure to albendazole. These results provide the basis for the loss of fecundity in A. suum after exposure to albendazole resulting in control in the population of the parasitic nematode.
Highlights
Helminth infections of livestock and humans cause serious economic loss and disease throughout the world
Control of Ascaris lumbricoides var. suum (A. suum) parasites, using the benzimidazole anthelmintic albendazole, is mediated through the selective binding to nematode β-tubulins (Lacey, 1990). This results in inhibition of polymerization and prevents the formation of microtubules and cell division (Shrestha et al, 2016)
Disruption of microtubules leads to loss of chromosome segregation and disruption of kinetochore function during meiosis resulting in aneuploidy, infertility and loss of fecundity (Dawson et al, 1984; Morrissette et al, 2004; Lyons-Abbott et al, 2010)
Summary
Helminth infections of livestock and humans cause serious economic loss and disease throughout the world. Suum (A. suum) parasites, using the benzimidazole anthelmintic albendazole, is mediated through the selective binding to nematode β-tubulins (Lacey, 1990). This results in inhibition of polymerization and prevents the formation of microtubules and cell division (Shrestha et al, 2016). Disruption of microtubules leads to loss of chromosome segregation and disruption of kinetochore function during meiosis resulting in aneuploidy, infertility and loss of fecundity (Dawson et al, 1984; Morrissette et al, 2004; Lyons-Abbott et al, 2010). The loss of the cytoplasmic microtubules results in the death of the nematodes (Shrestha et al, 2016) and interferes with other cellular functions including metabolism and cellular transport of proteins (Amini et al, 2014). Albendazole has been used as anticancer and antiparasitic drugs (Jordan & Kamath, 2007; Sant’anna et al, 2013)
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