Abstract
The parabiosis model, a surgical technique that has been in use for 150 years, has emerged as a helpful tool for examining the complex interactions across many biological systems. Through the surgical fusion of the circulatory systems of two viable species, commonly mice, this methodology facilitates the transfer of blood, cells, and soluble components between the interconnected entities. This comprehensive review provides a thorough examination of the parabiosis model, including its historical development and various applications in contemporary research. Additionally, it delves into the role of the parabiosis model in elucidating the potential rejuvenating effects of young blood on aged tissues, as well as its implications for age-related diseases. The study aims to elucidate the significant insights that have been provided by the mouse parabiosis model and underlines its promise as an experimental platform for deciphering the intricacies of inter-species interactions. The field of study exhibits promising potential for future discoveries, providing vital knowledge that has the potential to lead to new achievements.
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