Abstract
The experimental model of parabiosis, which is set up through joining two animals by surgical operation, develops a common and shared circulatory system. The blood cells and soluble factors can exchange continuously at physiological levels through their intercommunicated blood circulation. The parabiosis animal model is considered as a powerful model to observe the effect of circulating factors on organisms function. In the heterochronic parabiosis model, old mice exposed to a youthful systemic milieu exhibited rejuvenated organism function. And in the isochronic parabiosis model, it was observed that relative healthy systemic milieu affected the pathophysiological process of its attached partner. Key words: Parabiosis animal model; Milieu; Aging
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