Abstract
A 14C-tagged sample of a linear homopolymer of ethylene oxide of approximately 4,000,000 molecular weight, meeting the specifications of the commercial water-soluble resin material, was found not to be absorbed from the digestive tract of the rat and dog. The tagged sample contained 0.033% of glycols and 0.7% low molecular weight polyethylene glycols, matching in amount the activity found in rat urine. Commercial material was of low toxicity. The largest dosages fed rats and dogs for two years, 2.76 and 0.65 g/kg/day had no detectable effect, but in 90 days 8.0 and 18.4 g/kg/day were associated with minor kidney and liver effects in rats. Intravenous solutions of the commercial material killed rats in dosages as little as 3 mg/kg, but after strong agitation to shear the long linear polymer, 10 times the dosage was not lethal.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call