Abstract
Aim : To evaluate the effects of chlorpyriphos, lead acetate, vitamin C alone, and in combination on the activity of oxidative stress parameters in wistar rats. Marerial and Methods: Rats of 150-200g body weight were divided into eight groups of six animals each and were subjected to various daily oral treatment regimes for 98 days. Group I served as control receiving only corn oil, group II received th chlorpyriphos @ 5.5 mg/ kg in corn oil, group III received lead acetate @100 ppm in water, whereas animals in group IV th received a combination of chlorpyriphos @ 5.5mg/kg in corn oil and lead acetate @ 100 ppm in water. Group V received th vitamin C @ 100mg/kg in water, group VI received a combination of chlorpyriphos @ 5.5mg/kg and vitamin C @ th th 100mg/kg , group VII received lead acetate @ 100 ppm in water and vitamin C @ 100mg/kg and group VIII received chlorpyriphos @ 5.5mg/kg , lead acetate @100ppm in water and vitamin C @ 100mg/kg. Results: Administration of both chlorpyriphos and lead acetate caused a significant decrease in oxidative stress parameters viz. blood glutathione, catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST) along with a significant increase in lipid peroxidation level when given alone or in combination. Conclusions: The study demonstrated that treatment of chlorpyriphos and lead treated rats with vitamin C significantly improved some of altered oxidative stress parameters revealing the protective effect of this vitamin C against oxidative stress induced by chlorpyriphos and lead.
Highlights
Organophosphates (OP) were first synthesized in Germany before the Second World War and there have been an estimated 300,000 severe pesticide poisoning events reported worldwide, mostly due to them
Group I served as control receiving only corn oil, group II received chlorpyriphos @ 5.5 mg/ kg.(1/25th LD50) in corn oil, group III received lead acetate @100 ppm in water, whereas animals in group IVth received a combination of chlorpyriphos @ 5.5mg/kg in corn oil and lead acetate @ 100 ppm in water
Association between oxidative stress and adverse health effects have been suggested for several groups
Summary
Organophosphates (OP) were first synthesized in Germany before the Second World War and there have been an estimated 300,000 severe pesticide poisoning events reported worldwide, mostly due to them. Organophosphates, among other pesticides are the most toxic to the vertebrates [1,2]. Poisoning occurs as a result of agricultural use, suicide or accidental exposure [3]. Apart from inhibition of cholinesterase and presence of cholinergic effects, oxidative stress has been reported by many authors as one of the adverse effects in poisoning by OP in both humans and animals. On the basis of relevant literature it is concluded, that determination of oxidative stress parameters can be useful for monitoring people exposed to OP professionally. Org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited
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