Abstract
Objective To establish the animal model of infection of C57BL/6 mice by a murine norovirus (MNV) strain MNV-CW1. Methods C57BL/6 mice were orally administrated with MNV-CW1 of 104 PFU or 102 PFU per mouse. After establishment of mice model, we observed the clinical signs of disease and detected the virus RNA in feces, serum and organs. Results MNV-CW1 cannot induce obvious clinical syndrome in C57BL/6 mice, such as fever, diarrhea and histophathological changes. MNV RNA was detected in fecal on day 1 or 2 after infection and the main infection sites were spleen and digestive system of mice. Conclusions An animal model of MNV-CW1 was established and it will provide a basis for the further study of molecular pathogenesis of MNV infection. Key words: Murine norovirus, MNV; mouse; experimental infection
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