Abstract
Apoptosis – programmed morphological manifestation of neuronal death is associated primarily with the normal functioning of the central nervous system. However, a number of pathological states, including cerebral ischemia, significantly increases the level of apoptosis. The aim of this study was to investigate the mechanisms of cerebroprotective action of the drug «Capicor» – the study of apoptosis in the ischemic brain tissue of animals after acute cerebrovascular accidents.As a result of histomorphological and immunohistochemical studies revealed that «Capicor» at the dose of 56.5 mg/kg has neuro- and glioprotective properties, ensures the qualitative and quantitative structure of the brain tissue, the functionality of neurons in an area of ischemia, prevents necrosis and hinders the development of apoptotic processes. Anti-apoptotic component plays an important role in the mechanism of the cerebroprotective action of «Capicor». The level of cerebroprotective activity of the «Capicor» jointly investigated parameters was significantly superior to an asset-reference of the drug γ-butyrobetaine, and a number of parameters – the influence of trimethylhydrazinium propionate
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