Evidence of proatherogenic inflammation in vascular endothelium of caviae porcellous infected with helicobacter pylori and exposed to high fat diet

Abstract

Background and Aims : Atherosclerosis is a lipid-driven inflammatory disease of vascular endothelium. Various infectious agents, including Helicobacter pylori (HP), have been linked to atherosclerotic vascular disease, therefore the inflammatory aspect of Coronary Heart Disease is fundamental. The research done by our team indicated that bacterial components of HP and high fat substances acted synergistically in the initiating an early proatherogenic changes in the vascular endothelium. We were also the first group to show that HP antigens promoted macrophage transformation into foam cells.