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Abstract
Evaluation of the neurobehavioural and Histo-architecture changes of the hippocampus and pancreas of the streptozotocin-induced diabetic male wistar rats responding to Z. Officinale extract
Highlights
IntroductionAccording to the World Health Organization (1) over 422 million people around the world have diabetes
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycaemia and dyslipidaemia which results from defects in both insulin secretion and/or insulin action and is a complex endocrinemetabolic and multi-factorial disorder [1]
In 2012, an estimated 1.5 million deaths were directly caused by diabetes and another 2.2 million deaths were attributable to high blood glucose
Summary
According to the World Health Organization (1) over 422 million people around the world have diabetes. The number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014. Global prevalence of diabetes among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. More than 14 million people in the African region are diabetic and by 2040, this figure would have doubled [2]. In the year 2015, there were more than 1.56 million cases of diabetes in Nigeria. Long-term hyperglycaemia is an important factor in the development and progression of micro and macro-vascular complications, which include neuropathy (diabetic neuropathy), nephropathy, cardiovascular and cerebrovascular diseases, [2]
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