Abstract
Background: Hyaluronic acid (HA) plays a crucial role in skin health: it moisturizes, supports connective tissue and supports collagen production. With increasing age, HA levels decrease leading to wrinkles and a loss of facial volume. Hyal System DUO, an HA-based filler, addresses these defects through a unique combination of auto-crosslinked HA and BDDE-crosslinked HA. Purpose: To evaluate the safety, tolerability, and long-term performance of the HA-based filler in correcting facial wrinkles and restoring volume, turgor and elasticity to the skin. Materials and Methods: In a single-center observational study, 27 subjects were examined who were treated with the HA-based dermal filler in various areas of the face. Performance was assessed at six visits using the Wrinkle Severity Rating Scale (WSRS), the Facial Volume Loss Scale (FVLS), and the Global Aesthetic Improvement Scale (GAIS). Safety was monitored by recording adverse events.
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