Evaluation of the Filling Effects and Safety of an Injectable Gel Based on A Multi-Crosslinked Hyaluronan (Mu.C.H) Technology for the Correction of Facial Ageing Defects

Abstract

Background: Hyaluronic acid (HA) plays a crucial role in skin health: it moisturizes, supports connective tissue and supports collagen production. With increasing age, HA levels decrease leading to wrinkles and a loss of facial volume. Hyal System DUO, an HA-based filler, addresses these defects through a unique combination of auto-crosslinked HA and BDDE-crosslinked HA. Purpose: To evaluate the safety, tolerability, and long-term performance of the HA-based filler in correcting facial wrinkles and restoring volume, turgor and elasticity to the skin. Materials and Methods: In a single-center observational study, 27 subjects were examined who were treated with the HA-based dermal filler in various areas of the face. Performance was assessed at six visits using the Wrinkle Severity Rating Scale (WSRS), the Facial Volume Loss Scale (FVLS), and the Global Aesthetic Improvement Scale (GAIS). Safety was monitored by recording adverse events. Results: The HA-based filler showed significant and sustained performance in reducing wrinkles and restoring facial volume over the entire study period. Subject satisfaction was consistently high, with self-reported improvements consistent with physician’s assessments. Adverse events were mild and transient, demonstrating the safety of the product. The cross-linking technologies in this HA-based filler contributed to its lasting effect, providing a natural improvement for facial rejuvenation.