Abstract
The inherent efficiency of the N-spiro C2-symmetric chiral quaternary ammonium salt (S,S)-3 [(S,S)-β-Np-NAS-Br] has been evaluated in the representative organic-aqueous liquid-liquid phase-transfer benzylation and allylation of glycine tert-butyl ester benzophenone Schiff base (1). This revealed the practical conditions for the asymmetric synthesis of both natural and unnatural α-amino acids, whose usefulness was demonstrated by the formal enantioselective synthesis of antibiotic L-azatyrosine.
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