Evaluation of the efficacy of combination of biapenem and levofloxacin in the treatment of severe pneumonia in patients with multidrug-resistant Pseudomonas aeruginosa

Abstract

Objective To observe the clinical efficacy of combination of biapenem and levofloxacin in the treatment of severe pneumonia caused by multi-drug resistant Pseudomonas albuginea.In order to provide effective treatment for the patients with severe pneumonia resulted from resistant Pseudomonas albuginea. Methods Sixty patients with severe pneumonia were enrolled in this study.All patients had multiple drug resistant Pseudomonas aeruginosa infection.They were randomly divided into two groups according to the digital table method, 30cases in each group.All patients were treated with mechanical ventilation, anti-infection, phlegm, asthma and hemodynamic stability.The control group was treated with cefperazone-sulbactam and levofloxacin.The treatment group was treated with biapenem and levofloxacin.The body temperature, white blood cell count(WBC) and procalcitonin(PCT) level, oxygenation index(PaO2/FiO2), the total clinical effective rate, pulmonary rales disappeared time and the time of chest radiograph showing the pulmonary exudate absorption significantly were compared before treatment and 7 days after treatment. Results After treatment, the WBC, body temperature, PCT, PaO2/FiO2 of the control group were (13.16±2.89)109/L, (37.58±0.92)℃, (195.36±10.63), (9.36±1.56)μg/L, respectively, which of the treatment group were (5.36±2.65)×109/L, (36.41±0.52)℃, (235.14±8.65), (5.63±1.69)μg/L, respectively, and the differences between the two groups were statistically significant(t=2.72, 2.93, 2.82, 3.25, all P<0.05). The total effective rate was 40.0% in the control group and 56.7% in the treatment group.The difference was statistically significant(χ2=12.64, P<0.01). The time of reduction of lung rales in the lungs and the obvious absorption time of chest radiographs in the control group were (9.35±3.25)d, (10.63±1.57)d, respectively, which in the treatment group were (5.87±1.46)d, (7.65±1.87)d, respectively, the differences between the two groups were statistically significant (t=2.31, 2.45, all P<0.05). Conclusion The clinical effect of biapenem and levofloxacin is better than cefoperazone sulbactam combined with levofloxacin in the treatment of patients with severe pneumonia result from multidrug-resistant Pseudomonas aeruginosa. Key words: Pneumonia; Drug therapy, combination; Pseudomonas aeruginosa; Biapenem; Levofloxacin