Evaluation of the efficacy of a locally formulated antiseptic, for the control of disease-causing microorganisms

Anthonia E Eseyin,Benjamin O Omale,Juliet D Dodo

doi:10.14419/ijac.v8i2.31192

Anthonia E Eseyin, Benjamin O Omale + Show 1 more

Open Access

https://doi.org/10.14419/ijac.v8i2.31192

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Abstract

An antiseptic (sample A) was locally formulated. Its efficacy on the following micro-organisms; E.Coli, staphylococcus, streptococcus and bacillus species was evaluated and compared with that of Dettol and Septol. Sample A was established to be a cheap and effective antiseptic, which is capable of competing favourably with those in the Nigerian market. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) indicated that Sample A had a similar efficacy with Dettol. The P-value of the MIC results for samples A, Dettol and Septol were 0.004, 0.268 and 0.080 respectively, while the P-value of the MBC results were 0.450, 0.077 and 0.043 respectively. The standard errors of the mean were 0.079, 0.072 and 0.086 for sample A, Dettol and Septol respectively.Â Â

Highlights

An antiseptic is a chemical agent that slows or stops the growth of micro-organisms on external surfaces of the body and helps to prevent infections
Antiseptics should be distinguished from antibiotics, which destroy micro-organisms inside the body, and from disinfectants, which destroy micro-organisms found on inanimate objects
This study aims at locally formulating and evaluating the efficacy of a new, effective and affordable liquid antiseptic, using Chloroxylenol as an active ingredient and to compare the efficacy of the antiseptic formulated, with some of those in the Nigerian market

Summary

Introduction

An antiseptic is a chemical agent that slows or stops the growth of micro-organisms on external surfaces of the body and helps to prevent infections. Antiseptics and disinfectants are used extensively in hospitals and other health care centers to control the growth of microbes on both living tissues and inanimate objects. They are essential parts of infection control practices and aid in the prevention of nosocomial infections (Larson & Morton 1991). Many antiseptics in the Nigerian market today, have varying degrees of efficacy; which may be attributable to their active ingredients. This study aims at locally formulating and evaluating the efficacy of a new, effective and affordable liquid antiseptic, using Chloroxylenol as an active ingredient and to compare the efficacy of the antiseptic formulated, with some of those in the Nigerian market

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