Evaluation of Statin Therapy on Lipid Profile of Diabetic Dyslipidemia Patients

Abstract

The incidence of diabetes mellitus in Indonesia continues to increase. Diabetic dyslipidemia, as one of the complications, significantly increase the risk of developing cardiovascular disease causing 65% of death in diabetes patients. This study evaluated the statin therapy and comorbidity factors on lipid profile of diabetic dyslipidemia patients. A cross-sectional study consisted of patients who received and did not received statin therapy. The achievement of LDL cholesterol target was determined according to the ATP III guidelines. Related comorbidity factors were also evaluated. There were 36 patients (12%) who received statin therapy and 86 patients (28.7%) who did not receive statin therapy, achieving the LDL cholesterol target. The achievement of LDL cholesterol target was associated with the presence of statin therapy (p = 0.000). Stroke, hypertension, and peripheral arterial disease (PAD) as the comorbidity factors were not associated with these variables, while coronary heart disease (CHD) was associated with the presence of statin therapy (p = 0.008), the achievement of LDL cholesterol target (p = 0.007), and the duration of statin therapy (p = 0.022). The achievement of LDL cholesterol target was associated with the presence of statin therapy. CHD as the comorbidity factors was associated with the presence of statin therapy, the achievement of LDL cholesterol target, and the duration of statin therapy.