Evaluation of Reduced Glutathione Plasma Level in Type 2 Diabetic Patients with Fatty Liver

Abstract

Abstract Type 2 diabetes (T2DM) and its complications represent a main worldwide public health challenge, with high-rate morbidity and mortality. Non-alcoholic fatty liver disease (NAFLD) has a great focus worldwide, as it is expected to affect 75% of patients with type2 diabetes mellitus. In this study, we aimed to assess reduced glutathione plasma level then evaluate its correlation with fasting blood glucose levels, HBA1c and lipid profile in type 2 diabetic patients with fatty liver. This study included 40 participants divided into 20 type2 diabetics with fatty liver group and 20 healthy control group. Estimation of fasting blood glucose levels, HBA1c, lipid profile and liver function enzymes were done. reduced glutathione plasma levels were measured by ELISA. The results revealed that plasm levels of reduced glutathione were lower in type 2 diabetics with fatty liver compared to control subjects (P < 0.01). These low plasma GSH levels in diabetics was negatively correlated with FBG and HBA1C% (r= −0.641, −.0547 respectively; P < 0.01) indicating that chronic hyperglycemia and its resulted oxidative stress have negative impact on GSH concentrations in the body. This low GSH levels in type 2 diabetics with fatty liver can be an important prognostic factor as, GSH reduction causing increase of oxidative stress and may worsen the liver status that may progress to NASH.