Abstract
Background: The Type 2 diabetes mellitus is becoming more and more prevalent in our country India and it is estimated that approximately around 2% of the Indian population i.e around 15 million peoples are suffering from this disease and Glycated hemoglobin (HbA1c) is routinely used as a diagnostic tool for screening and measuring long term control in diabetic patient. Aim: The study was planned to observe the relationship among Glycated hemoglobin (HbA1c), Fasting blood sugar and Lipid profile in Type 2 diabetics of western U.P population. Material and Methods: Data of around 92 males and 112 females, from the age group of 25 to 55 years were selected from December 2014 to July 2016 in a cross sectional manner. Blood sample (3ml) was collected from each subject. Serum was separating by centrifuging blood at 3000 rpm for 10 min. Fasting blood sugar and Lipid profile were estimated by Vitros 250 auto analyzer using readymade dry chemistry kits from Ortho Clinical diagnostics, Johnson & Johnson, USA and HbA1c with kit based method. Result: Mean value of HbA1c in control subjects was 4.62 0.18 and 5.78 0.19 in diabetic subjects, HbA1c values were significantly higher in Diabetic subjects (<0.001) as compared to control subjects. The mean value of FBS in Diabetic subjects was 115.72 3.83 and 92.33 3.61 in control subjects. Also, FBS mean value was found to be significantly lower in control group (<0.001) as compared to Diabetic subjects. Conclusion: Our study demonstrates that, altered Lipid profile has been associated with elevated levels of Fasting blood glucose. Thus, the adverse effect of hyperglycemia and associated dyslipidemia must not be overlooked in Diabetic subjects.
Highlights
In the ancient Sanskrit Indian literature, Diabetes Mellitus (DM) was described as “honey-urine disease” and has been associated with gross emaciation and wasting
An estimated 300,000 peoples die from diabetes due to its severe complications because of uncontrolled hyperglycemia
Results of our study shows that the level of LDL, TC & TG were significantly higher in Type 2 diabetics, which is in accordance with the study conducted by Wexler et al.[7]
Summary
In the ancient Sanskrit Indian literature, Diabetes Mellitus (DM) was described as “honey-urine disease” and has been associated with gross emaciation and wasting. Diabetes mellitus is becoming more and more prevalent in our country India, it is estimated that approximately around 2% of the Indian population i.e around 15 million peoples are suffering from diabetes and the number of cases is said to be alarmingly rising day by day by around 5%-6% each year. The Type 2 diabetes mellitus is becoming more and more prevalent in our country India and it is estimated that approximately around 2% of the Indian population i.e around 15 million peoples are suffering from this disease and Glycated hemoglobin (HbA1c) is routinely used as a diagnostic tool for screening and measuring long term control in diabetic patient. Aim: The study was planned to observe the relationship among Glycated hemoglobin (HbA1c), Fasting blood sugar and Lipid profile in Type 2 diabetics of western U.P population.
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