Abstract
Bovine papillomatosis is an infectious viral disease caused by Bovine Papillomavirus (BPV). Single nucleotide polymorphisms (SNPs) in genes responsible for innate immunity have been the object of several studies and present great importance in the susceptibility of animals to disease development. Mannose-binding lectins (MBLs) are lectins involved in the innate immune response against various infectious agents, including viruses. Due to the fact that polymorphisms in the MBL2 gene may affect the functionality of the protein, the present study aimed to evaluate the association of MBL2 gene exon 1 polymorphisms with susceptibility to bovine papillomatosis. Blood samples of 167 Brazilian Girolando breed animals (Gir x Holstein) from the Northeast of Brazil were used. All animals were infected with BPV, of which 92 animals were affected by cutaneous papillomatosis and 75 animals did not have cutaneous lesions. The analysis revealed 245 conserved sites and 02 variable sites, G235A and T244C, in the MBL2 gene exon 1. The allelic and genotypic frequencies of the two SNPs showed no association of these SNPs with susceptibility to cutaneous papillomatosis.
Published Version
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