Evaluation of platelet count and platelet indices in patients with coronary artery disease

Jasmin H Jasani,Yash Shah,Madhur Modi,Hetal Vaishnani,Denish Vachhani,Rushabh Patel,Vasundhara Bhruguvanshi,Bhumika Gharia,Deval Patel

doi:10.7439/ijbar.v5i11.978

Abstract

Background: Ischemic heart disease is mainly caused by atherosclerosis and its complications. Platelets and their activity have an important role in initiation of atherosclerotic lesions and coronary thrombus formation. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets. Aims: To study the changes in platelet volume indices and platelet count in ischaemic heart disease and assess their usefulness in predicting coronary events. Methods: This was a comparative study of 180 patients (60 patients with stable angina, 60 with acute coronary syndrome and 60 with non-cardiac chest pain). Blood venous sample were drawn from all subjects after admission and collected in EDTA tubes. Platelet count and volume indices were assayed within 30 min of blood collection, using Nihon Kohden autoanalyzer. Results : All platelet volume indicesmean platelet volume (MPV), platelet distribution width (PDW), and platelet concentrate (PCT)were significantly raised in patients with AMI and UA. In patients with myocardial infarction, the mean values of MPV, PDW, platelet count and PCT were 11.02fL, 17.85%, 2.61 lac/cumm and 0.34% respectively. In patients with unstable angina were 10.31fL, 16.75%, 2.3 lac/cumm and 0.36% respectively while in normal healthy control the mean values of these indices were 7.98 fL, 10.70%, 2.66 lac/cumm and 0.24% respectively. Conclusions: Patients with acute coronary syndrome had higher platelet volume indices and lower platelet counts compared with those with stable angina and the normal population. Measurements of platelet volume indices and platelet count may be of some benefit in detecting those patients at higher risk for acute coronary events.

Highlights

Platelet activation plays a central role in the transformation of atherosclerotic cardiovascular disease (CVD) into its potentially major adverse clinical events, such as ischemic stroke and myocardial infarction (MI)1-3,Increased platelet activation may represent the net pathophysiological effects of a number of CVD risk factors, such as smoking and raised cholesterol, representing a broad marker of CVD risk[4].Platelets play a key role in the development and progression of cardiovascular disease, with increased aggregation and activation occurring in patients with chronic stable angina and acute coronary syndrome (ACS)[5]
It has been postulated that large platelets may be an indicator of platelet activation, and be related to the extent and clinical presentation of coronary artery disease (CAD)[8]
The degree of platelet activation may be assessed by platelet indices such as platelet count, mean platelet volume (MPV)

Summary

Introduction

Platelet activation plays a central role in the transformation of atherosclerotic cardiovascular disease (CVD) into its potentially major adverse clinical events, such as ischemic stroke and myocardial infarction (MI)1-3 ,Increased platelet activation may represent the net pathophysiological effects of a number of CVD risk factors, such as smoking and raised cholesterol, representing a broad marker of CVD risk[4].Platelets play a key role in the development and progression of cardiovascular disease, with increased aggregation and activation occurring in patients with chronic stable angina and acute coronary syndrome (ACS)[5]. Ischemic heart disease is mainly caused by atherosclerosis and its complications Platelets and their activity have an important role in initiation of atherosclerotic lesions and coronary thrombus formation. Aims: To study the changes in platelet volume indices and platelet count in ischaemic heart disease and assess their usefulness in predicting coronary events. In patients with myocardial infarction, the mean values of MPV, PDW, platelet count and PCT were 11.02fL, 17.85%, 2.61 lac/cumm and 0.34% respectively. Conclusions: Patients with acute coronary syndrome had higher platelet volume indices and lower platelet counts compared with those with stable angina and the normal population. Measurements of platelet volume indices and platelet count may be of some benefit in detecting those patients at higher risk for acute coronary events.

Objectives

Methods

Conclusion