Evaluation of phytochemicals from Morinda citrifolia (Noni) fruit extracts against nicotine-induced different physiological functions: An experimental study on albino rat model

Abstract

Background: People are consuming nicotine in the form of cigars, pipes and, cigarettes etc. and they are suffering from lungs, liver, heart diseases, involving hidden killer for human health. The Morinda citrifolia (Noni) is an important medicinal plant of the Rubiaceae family, commonly known as Ach, Bartundi, Hurdi and Sarangi in Bengali. Traditionally it is used in various purposes of food and medicines.Aims and objectives: The present study was undertaken to highlight and find out the different phytochemicals from noni fruit extractand its role against nicotine-induced cardiac damage, mainly serum lipid profile and hematological changes and development of biobased anti-nicotinic agent is now become an active research goal.Materials and methods: Fruits of the selected plant was collected and prepared methanolic fruit extract. Fruit of M. citrifolia (Noni)contains several nutrients and phytochemicals. GC-MS analyzed the methanolic fruit extract of M. citrifolia to determine chemicalconstituents. The noni fruit extract was applied against the rat model’s nicotine-induced blood parameters.Results and discussion: Hematological and Biochemical alteration of cardiovascular experiments was done in albino rat. This studyrevealed that the fruits extract of M. citrifolia may be capable of reducing the cholesterol and hemoglobin levels significantly (p<0.05)in blood after nicotine treatment in rat models.Conclusion: So, we try to find out the role of active principles and phytochemicals from this plant to combat the nicotinic activity.Results show that Noni fruit methanolic extract may have some protective effects against nicotine and its action.