Abstract
Background and objective: exposure to lead continues to a serious public problem. The objective is to elucidate the effect of lead acetate exposure on serum Concentration of urea and creatinine in adult female rats.Methods: Forty eight adults female rats divided in to four groups (12 rats/group) .Group 1, (T1) ,given date palm pollen (150 mg/kg. B.W.) Group 2,(T2) given lead acetate (10mg/kg. B.W.), group 3, (T3) given lead acetate (10mg/kg.B.W.) and date palm pollen (150 mg/kg. B.W) for 6 weeks, Group 4(Control) ,given distilled water. Serum concentration of urea and creatinine was evaluated via ELISA method for all groups.Results: The mean concentration of urea showed no significant difference between,(T1) and (T3) while in T2 a significant (p < o.o5) increase in urea concentration compared to T1&T3 . There was no significant difference within groups in urea concentration. Group (T1) exposed to DPP showed no significant decrease in serum creatinine on zero,14 , 28 day & 42 day post exposure respectively . Group (T2) exposed to lead acetate showed significant increase of creatinine concentration compared with control and (T1) group .Group (T3) showed significant decrease in creatinine levels compared with T2 group and these levels become closely to control group. Histological changes indicated that DPP significantly meliorate the toxic effects of lead acetate in glomeruli, collecting tubules associated with obvious decrease in inflammatory response.Conclusion: DPP has the ability to counteract the toxic effect of lead acetate associated with improvement of renal histology and serum concentration of urea and creatinine.
Highlights
Antioxidant activity is recognized due to the wide range of phenolic compounds present in dates including p-coumaric, ferulic, and sinapic acids, flavonoids, and procyanidins[1][2]
The mean concentration of urea showed no significant difference between,(T1) and (T3) groups along all period of experiment while group T2 caused a significant (p
In Table 2animals of group (T1) exposed to Date palm pollen (DPP) for 6 weeks showed no significant decrease in serum creatinine on day zero, 14 and 28 day of treatment period exposed the last period (42 day) while group (T2) exposed to lead acetate showed significant increase of creatinine concentration compared with control and (T1) group
Summary
Antioxidant activity is recognized due to the wide range of phenolic compounds present in dates including p-coumaric, ferulic, and sinapic acids, flavonoids, and procyanidins[1][2]. The prevention of action of free radical is important step in the management of disease Medicinal plant and their constituents play a vital and significant action to neutralize or inhibit the free radical by the use of antioxidant activity[5]. Date palms play a significant role in neutralization of free radical and suppress the various types of diseases development and progression. The objective is to elucidate the effect of lead acetate exposure on serum Concentration of urea and creatinine in adult female rats. Group (T1) exposed to DPP showed no significant decrease in serum creatinine on zero, 14, 28 day & 42 day post exposure respectively. Conclusion: DPP has the ability to counteract the toxic effect of lead acetate associated with improvement of renal histology and serum concentration of urea and creatinine.
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