Abstract
This study was designed to evaluate the ameliorative role of betaine on hepatic and renal dysfunction caused by acrylamide in female rats. Thirty two (32) adult female rats were randomly and equally divided into four groups (G1, G2, G3 and G4) and were treated for (65) days as following: Group G1 (Control group), G2: rats were intubated 250mg/kg B.W of betaine; animals in group G3 were intubated 1mg/kg B.W of acrylamide, in addition to acrylamide. 250mg/kg B.W of betaine were administered orally to rats in groups G4. Fasting (8-12 hrs.) blood samples were collected by cardio puncture technique at the end of the experiment, serum were collected for measuring the following parameters A: liver enzyme makers; serum activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) B; renal function parameters including: serum creatinine, urea and uric acid concentration. The hepato and renal protective effect of betaine was clarified in groups (G2 and G4) manifested by significant decrease in serum, ALT, AST and ALP activity, as well as significant decrease in serum creatinine, urea and uric acid concentration comparing to acrylamide (G3) treated group. Such functional changes were accompanied with structural (histopathological) alteration in hepatic and renal tissue. In conclusion, the results of the current study documented the negative effect of acrylamide on liver and kidney function and documented hepatorenal protective effect of betaine.
Highlights
Betaine is found in common food, including vegetables, bran, seafood and wheat germ [1]
Previous studies that hepatoprotective role from free radical which produces from the oxidative stress which the main factor to liver injury (7 - 9)
Statistical analysis of data was performed on the basis of one-Way Analysis of Variance (ANOVA) using a significant level of (P
Summary
Betaine is found in common food, including vegetables, bran, seafood and wheat germ [1]. Betaine is a potential medical therapeutic for the alcohol-induced simple fatty liver [13]. It possesses hypolipidemic and antioxidant effect in acrylamide treated rats [14]. Last metabolite is genotoxic leading to the finishing of hemoglobin and glycidamideDNA adducts [19] It accumulates at higher levels in the blood than any other tissues following exposure via oral ingestion, inhalation, or via the dermis [20]. Low level expose of human to AA along like high different food source, smoking and environment exposure increase its hazard effect on human health this study was designed to investigate the protective action of betaine towards AA caused hepatic and renal damage. Oral intubation of 1mg/kg B.W ACR exaggerates metabolic syndrome parameters including dyslipidemia and hyperuricemia [31], as well as hypercholesterolemia and central obesity [32]
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