Abstract
Objective: Numerous investigations suggest that Mesenchymal Stem Cells (MSCs) in general represent a valuable tool for therapy of symptoms related to chronic inflammatory diseases. Blue Horizon Stem Cell Therapy Program is a leading provider of adult and children’s stem cell therapies. Uniquely we have safely and efficiently treated over 600 patients with documenting each procedure. Methods: The purpose of our study is primarily to monitor the immune response in order to validate the safety of intravenous infusion of human umbilical cord blood derived MSCs (UC-MSCs), and secondly, to evaluate effects on biomarkers associated with chronic inflammation. Twenty patients were treated for conditions associated with chronic inflammation and for the purpose of anti-aging. They have been given one intravenous infusion of UC-MSCs. Results: Our study of blood test markers of 20 patients with chronic inflammation before and within three months after MSCs treatment demonstrates that there are no significant changes and MSCs treatment was safe for the patients. Analysis of different indicators of chronic inflammation and aging included in initial, 24-hours, two weeks and three months protocols showed that stem cell treatment was safe for the patients; there were no adverse reactions. Moreover, data from follow-up protocols demonstrate significant improvement in energy level, hair, nail growth and skin conditions. Conclusion: Intravenously administered UC-MSCs were safe and effective in the improvement of symptoms related to chronic inflammation. Further close monitoring and inclusion of more patients are necessary to fully characterize the advantages of UC-MSCs application in treatment of symptoms related to chronic inflammation.
Highlights
Prolonged inflammation, known as chronic inflammation, is characterized by continued active inflammation response and tissue destruction
Isolation of Mesenchymal Stem Cells (MSCs) from umbilical cord bloods: Cord blood sample was diluted with phosphate buffer saline (PBS) (1:1). 15 mL of FicollHypaque pipetted into a 50 mL conical centrifuge tube. 30 mL of the mixture of PBS and sample slowly layered over the Ficoll-Hypaque and centrifuged 30 min at 450 g
MSCs were isolated from umbilical cord bloods from healthy births
Summary
Known as chronic inflammation, is characterized by continued active inflammation response and tissue destruction. Neutrophils and eosinophils are involved directly or by production of inflammatory cytokine production in pathology of chronic inflammation [1]. Regulated inflammatory responses are essential to maintain homeostasis. Inflammatory responses that fail to regulate themselves can become chronic and contribute to progression of disease [2]. Numerous investigations suggest that Mesenchymal Stem Cells (MSCs) represent a valuable tool for therapy in chronic inflammatory diseases. MSCs, multipotent adult stem cells, feature the potential to regenerate tissue damage and inhibit inflammation. MSCs can be safely transplanted in autologous and allogeneic ways as they are non-immunogenic, representing a therapeutic option for chronic inflammatory diseases. There are more than 200 registered clinical trial sites for evaluating MSC therapy, and 22 are on autoimmune diseases [4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
