Abstract
Objective: In the present study Hepatoprotective activity of Ethanolic Extract of flower of Nymphaea alba Linn were investigated. Material & Method: The hepatoprotective activity of Ethanolic Extract of flower of Nymphaea alba were evaluated by Carbon Tetra Chloride & Paracetamol induced hepatotoxicity in experimental rats. The Etnanolic Extract of Nymphaea alba (200 & 400 mg/kg) treat the hepatotoxicity and produced significant inhibition in the wet liver weight and wet liver volumes and the serum enzymes (SGOT, SGPT & ALP), bilirubin and cholesterol levels. Result: Preliminary phytochemical analysis of Ethanolic Extract of Nymphaea alba revealed that the presence of various phytoconstituents Alkaloids, Carbohydrates (Polysaccharides), Glycosides, Steroids, Flavonoids and Tannin & Phenolic compound. The ethanolic extract (200 & 400 mg/kg) showed significant reduction in SGOT, SGPT, ALP, Bilirubin & cholesterol level as compared to control group. Maximum inhibition was obtained at dose 400 mg/kg of Ethanolic Extract of Nymphaea alba in both model. Conclusion: The present study suggests that Ethanolic Extract of flower of Nymphaea alba Linn possess strong and potential Hepatoprotective activity in both model. So it has immense scope as an effective source to develop drug for the treatment of liver related diseases. These results may further suggest that ethanolic extract was found to possess hepatoprotective activity.
Highlights
Liver is the largest gland and heaviest gland of the body weighing about 1.4 kg in an average adult
The liver is the main site of metabolism for drugs and other exogenous compounds
Ethanolic Extract of Nymphaea alba Linn (EENA) at 200 mg/kg and 400 mg/kg p. o. for 7 days had produced significant protective effect on CCl 4 -induced hepatic damage by maintaining the morphological changes and normalizing the elevation of serum biochemical parameter and inhibited the Histopathological abnormalities caused by CCl4
Summary
Liver is the largest gland and heaviest gland of the body weighing about 1.4 kg in an average adult. The liver is the main site of metabolism for drugs and other exogenous compounds. The leaves may be up to thirty centimeters in diameter and they take up a spread of 150 centimeters per plant It is an aquatic herb with perennial rhizomes or rootstocks anchored with mud. It is globally distributed in Europe, North Africa, Southwest Asia, India, China and Russia. It is rich in tannic acid, gallic acid, alkaloids, sterols, flavonoids, glycosides, hydrolyzable tannins and high–molecular-weight polyphenolic compounds. All the parts of the plant have medicinal uses in traditional system of medicine It is used as an aphrodisiac, anodyne, antiscrophulatic, astringent, www.ssjournals.com cardiotonic, demulcent, sedative and anti-inflammatory. It produces calming and sedative effects upon the nervous system, and is useful in the treatment of insomnia, anxiety and similar disorders[3,4,5,6,7,8]
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