AKTIVITAS HEPATOPROTEKTIF EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) PADA TIKUS PUTIH YANG DIINDUKSI PARASETAMOL

Abstract

Paracetamol causes liver damage if consumed more than normal limits continuously. Liver damage is characterized by increased levels of the enzymes Serum Glutamic Pyruvic Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT) in the blood. Antioxidants can prevent paracetamol-induced liver damage. Telang flower (Clitoria ternatea) is a plant that has the potential to prevent liver damage because it has high antioxidant activity. This study aimed to examine the hepatoprotective activity of ethanol extract of telang flower in rats induced by paracetamol. Rats were grouped into 6 groups consisting of normal control without paracetamol induction, negative control, positive control, test doses 1, 2, and 3 were given paracetamol as much as 150 mg/200 g BW on day 1 to day 7. After 1 hour, the positive control group was given curliv 37 mg/200 g BW, test doses 1, 2, and 3 were given ethanol extract of telang flower, respectively 123 mg/200 g BW, 247 mg/200 g BW, and 370 mg/200g BW on day 1 until the 7th day. On the 8th day, the rat's blood was taken and then measured SGPT and SGOT were by an enzymatic method using a photometer. Based on the results of statistical analysis, Telang flower ethanol extract doses 1, 2, 3, and positive control showed a significantly different decrease in SGPT and SGOT compared to negative control but only dose 2 (247 mg/200 g BW) showed hepatoprotective activity equivalent to positive control.