Evaluation of effective Medhya formulation on trancranial treatment on rat

Abstract

2 and targeted to the brain through the scalp. The drugs are effective if it's delivered to the site of action, In the Ayurvedic system of medicine practices oil therapies to the head to treat diseases of the central nervous system 3 . The present study objective is to find out the effectiveness of few medhya (polyphyto) formulations for its learning and memory activity could be delivered and targeted to the brain by transcranial delivery route. In the formulation uses potential plants having efficacy to improve learning and memory are of Habiscus rosasinensis 4 Abstract The herbs that promote the intelligence are called Medhya herbs. This action is related to our mind and mind resides in the brain and nervous system - especially the higher cortical centers of the brain. According to Ayurveda the intelligence is a triad of three powers of the mind - the acquisition, the retention and the recollection. The unique anatomical arrangement of blood vessels and sinuses in the human skull and the brain, the prevalence of a high density of skin appendages in the scalp, extra cranial vessels of the scalp communicating with the brain via emissary veins and most importantly, the way that the scalp is used in the Ayurvedic medical system in treating diseases associated with the brain show that a drug could be transcranially delivered and targeted to the brain through the scalp. The present study objective is to find out the effectiv eness of the few medhya (polyphyto) formulations for its learning and memory activity could be delivered and targeted to the brain by transcranial delivery route. The transcranial medhya formulation; FM1 (Habiscus rosasinensis, Oscimum sanctum, Santalum album, Phyllanthus Emblica, Convolulus pluricaulis Bacopa monnieri, FM2 (Lactuca sativa, Juglans regia, Curcuma longa, Vigna mungo, Asphaltum vernacular), & FM3 (Mentha piperita, Juglans regia, Ribes nigrum, Zingiber officinalis, Aloe vera, Cinnamomum zeylanicum, Curcubita pepo, Glycine max, Avena sativa) on memory acquisition and retention was studied using Elevated plus maze, Morris water maze (MWM) and Pole Climbing apparatus (PCA) in rat. On Application of trancranial media formulations FM1& FM3 showed significant reduction in transfer latency in EPM, MWM and escape latency in PCA test as compared with the control and standard group, whereas FM2 is equally effective in comparison to standard drug but it shown an extremely signifi cant effect compared to control group.