Evaluation of brain aging by EEG analysis of photic driving response

Abstract

In this paper, we examined the possibility to estimate brain aging by EEG photic driving response. Normal subjects are classified into 3 age groups by age, 20's, 21 – 59, and over 60. We obtained the Z-score from EEG at rest and during photic stimulus (PS) by using the method for evaluating intraindividual EEG we have already proposed. Here, we showed the averaged Z-score of 3 age groups for 6 Hz PS as a representative example. As a results, in 20's, significant difference (|Z|>1.96, p<0.05) was recognized at fundamental and higher harmonic frequencies of PS frequency except second harmonic. With increase of age, we could see the decrease of Z-score at fundamental frequency and higher harmonics. In the group over 60, no significant difference at any frequencies was recognized.