Evaluation of arterial stiffness and related risk factors in healthy examination subjects

Abstract

Objective To investigate the possible risk factors involving pulse wave velocity (PWV) in healthy people.Methods 323 subjects from Shougang Corporation examination center were enrolled into our study.They were divided into two groups:PWV＜9 m/s(n=37)group and PWV ≥ 9 m/s(n=286) group.Carotid-femoral pulse wave velocity (CF-PWV) was detected by the Complior apparatus.Results The incidence of hypertension was significantly higher in PWV ≥ 9 m/s group.The levels of systolic blood pressure (SBP),diastolic blood pressure (DBP),pulse pressure (PP),triglycerides (TG) were significantly higher in PWV ≥ 9 m/s group than in control group [(141.2 ± 19.9)mmHg vs (129.0 ± 18.8)mmHg,P＜0.001;(88.4 ± 11.1)mmHg vs (82.1 ± 10.8) mmHg,P=0.001;(52.8 ± 12.9)mmHg vs (46.8 ± 10.6) mmHg,P=0.007;(2.13 ± 1.64)mmol/L vs (1.19 ± 0.73)mmol/L,P＜0.001)].High-density lipoprotein cholesterol (HDL-C) was higher in PWV＜9 m/s group.PWV was positively correlated with age,SBP,DBP,PP,glucose,HbA1c,uric acid,TG in the entire study group(γ =0.124,0.307,0.259,0.255,0.187,0.340,0.169,0.278,respectively,all P＜0.05).There was negative correlation between PWV and HDL-C in the entire group(γ=-0.283,P＜0.001).Multivariate analysis showed that SBP,HbA1c were significant independent associating factors of PWV in all subjects(β =0.314,P=0.003; β =0.307,P=0.003).Conclusion The levels of SBP,DBP,PP,TG were significantly higher in PWV ≥ 9m/s group than that in control group.HDL-C might play an important role in the development of arterial stiffness.More studies should be investigated in future. Key words: Pulse wave velocity; Arterial stiffness