Evaluation of aphrodisiac activity of AHPL/AYCAP/0114 capsule in sexually sluggish male rats

Abstract

Background: Male sexual dysfunction includes a wide range of problems such as erectile dysfunction and premature ejaculation, for which medical help is sought. The conventional use of various pharmacological and nonpharmacological measures are associated with multiple adverse events. Hence, a polyherbal formulation AHPL/AYCAP/0114 capsule was developed to provide safe and effective therapeutic option. Objectives: The aim of this study was to evaluate the aphrodisiac potential of AHPL/AYCAP/0114 capsule by assessing sexual behavior parameters such as mount frequency (MF), mount latency (ML), intromission frequency (IF), intromission latency (IL), ejaculation latency (EL), and ejaculation frequency (EF) in sexually sluggish male rats. Materials and Methods: Male Wistar rats were divided into six groups (n = 6) and treated with testosterone (30 mg/kg), sildenafil citrate (0.5 mg/kg), and AHPL/AYCAP/0114 capsule (110, 220, and 440 mg/kg) as Group II, Group III, and Group IV, V, and VI, respectively, for 28 days. Group I animals served as control. Then, they were introduced to sexually active female rats and their sexual behavior was recorded. Results: A significant increase in MF, IF, and EF was observed in all the AHPL/AYCAP/0114 capsule groups as compared to control group. A significant decrease in ML, IL, and EL was observed in all the AHPL/AYCAP/0114 capsule groups as compared to control group. AHPL/AYCAP/0114 capsule was well tolerated by rats. Discussion: Increase in MF, IF, and EF and reduction in ML, IL, and EL are indicative of increased sexual motivation and arousal and prolonged duration of coitus. This suggests enhanced sexual performance in sexually sluggish animals treated with AHPL/AYCAP/0114 capsule. Conclusion: It can be concluded that AHPL/AYCAP/0114 capsule possesses aphrodisiac activity and can be used in erectile dysfunction and loss of libido. Abbreviations used: (MF): Mount frequency; (ML): Mount latency; (IF): Intromission frequency; (IL): Intromission latency; (EL): Ejaculation latency; (EF): Ejaculation frequency; (ED): Erectile dysfunction; CPCSEA: Committee for the Purpose of Control And Supervision of Experiments on Animals.