Effect of the aqueous extract of the aerial parts of Monsonia angustifolia E. Mey. Ex A. Rich., on the sexual behaviour of male Wistar rats.

Gerda Fouche,Anthony J. Afolayan,Tendani E. Khorombi,Olubunmi A. Wintola,Jeremiah Senabe

doi:10.1186/s12906-015-0880-4

Gerda Fouche, Anthony J. Afolayan + Show 3 more

Open Access

https://doi.org/10.1186/s12906-015-0880-4

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Abstract

BackgroundMonsonia angustifolia (Geraniaceae) is a medicinal plant traditionally used in South Africa to increase libido and to treat erectile dysfunction.MethodsIn-vivo aphrodisiac activities of the crude extracts of the plant prepared in water at 3, 30 and 300 mg/kg body weight were evaluated for 7 days using sildenafil citrate (Viagra) and 1 % ethanol in distilled water as positive and negative controls respectively. Male rats were selected and monitored in each group for sexual behaviour by exposing them to sexually receptive females on days 1, 3 and 7 for 60 minutes each between 7:00 pm and 3:00 am. The following male sexual parameters were observed: Mount Frequency (MF), Intromission Frequency (IF), Mount Latency (ML), Intromission Latency (IL), Ejaculation Frequency (EF), Ejaculatory Latency (EL) and Post-Ejaculatory Interval (PEI).ResultsThe administration of the extract resulted in significant increase (p < 0.05) in mount frequency, intromission frequency, ejaculation frequency, ejaculation latency and serum hormone concentrations. The computed indices of sexual behaviour such as erection, quick flips, long flips and total penile reflexes were also increased. However, the mount latency, intromission latency and post ejaculation interval were significantly decreased throughout the experimental period. The administration of 300 mg/kg body weight of the aqueous extract produced the best effects in all the parameters.ConclusionGenerally, the extract of Monsonia angustifolia produced pro-sexual stimulatory effects in the male rats especially when administered at 300 mg/kg body weight. The results validate the use of the plant by the indigenous people to increase libido and treat premature ejaculation and erectile dysfunction in males.

Highlights

Monsonia angustifolia (Geraniaceae) is a medicinal plant traditionally used in South Africa to increase libido and to treat erectile dysfunction
The highest mount frequency (MF) was recorded in the rats administered with 300 mg/kg body weight and Viagra, followed by those administered with 30 mg/kg and least in those administered with 3 mg/kg (Fig. 1)
The two way Anova showed that duration of treatment on rats with extracts did not have any significant effect (P = 0.23) on intromission frequency

Summary

Introduction

Monsonia angustifolia (Geraniaceae) is a medicinal plant traditionally used in South Africa to increase libido and to treat erectile dysfunction. Sexual behaviour is one of the fundamental principles of reproduction comprising mating, sexual behaviour, fertility, conception and reprocration. Several substances have been reported to stimulate or increase sexual desire and performance [1, 2]. These substances include Levodopa (dopamine), Amyl nitrite, Vitamin E and Sildenafil citrate (Viagra). Despite several reports on the use of these conventional substances, loss of sexual desire in male partners may be more common than arousal and orgasm disorder [3]. (Geraniaceae) is a medicinal plant used to increase male and female libido Rich. (Geraniaceae) is a medicinal plant used to increase male and female libido

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