Abstract
Background: The contributions of host factors, such as age, in male infertility are still poorly understood. Thus, the present work has aimed to evaluate the effect of patient’s age on semen parameters of infertile males. Method: Semen samples from 52 infertile patients aged 21-52 years (mean 30.8 ± 6.7) were analysed by conventional semen analysis methods, flowcytometry analysis for sperm DNA integrity, and colorimetric assay for total antioxidant capacity. Results: The study revealed that, as patient’s age increases, there was a significant reductionin sperm density, motility, percentage of morphologically normal spermatozoa, total antioxidant capacity and DNA integrity. Conclusion: The study results demonstrated the negative influence of increasing patient’s age on semen parameters; and the possible role of patient’s age in the aetiology of male infertility.
Highlights
Infertility is a growing medical and social problem in the world; and approximately one of five couples has problems with conception [1]
Understanding the effect of male age on fertility has become increasingly important in public health because a growing number of men are choosing to father children at older ages [6]
The study was approved by the ethical review board of Arabian Gulf University
Summary
Infertility is a growing medical and social problem in the world; and approximately one of five couples has problems with conception [1]. Still unsatisfactory diagnostic strategy for male infertility causes is applied in many clinical centres in the world [3]. In the last few decades, there was growing concern about the possible threat of the environmental chemical and physical agents to male fertility. Factors such as genital infection, smoking, and radiotherapy are frequently disturb the biochemical events that occur during spermatogenesis [5]. Understanding the effect of male age on fertility has become increasingly important in public health because a growing number of men are choosing to father children at older ages [6]. The present work has aimed to evaluate the effect of patient’s age on semen parameters of infertile males
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