Abstract
Evaluation Effect of Silver Acetate on Performance and Clostridium Perfringens-Induced Necrotic Enteritis in Broiler Chickens
Highlights
Necrotic enteritis (NE) in broiler chickens is a bacterial infection caused by the Gram-positive, spore forming; anaerobic Clostridium perfringens type A (CP) within 2-6weeks of age [1]
One strategy followed by animal producers to reduce or control the enteric bacterial burden of CP and subsequently promotes the growth performance; diets have been fortified with antibiotics as a growth promotor (AGP) [5]
The objective of this study was to evaluate the potential effect of AgAc (Sigma-Aldrich, 99.9% purity; molecular weight 166.8g/mol) on broiler chicken performance, Clostridium perfringens colonization, and lesion score associated with NE
Summary
Necrotic enteritis (NE) in broiler chickens is a bacterial infection caused by the Gram-positive, spore forming; anaerobic Clostridium perfringens type A (CP) within 2-6weeks of age [1]. CP is frequently found in the intestinal tract of healthy poultry, usually at levels lower than 102-104 CFU/g of intestine content verses 107 -109CFU/g in diseased birds [2,3]. Both clinical and sub-clinical forms of NE are known to cause industry losses of approximately US$6 billion annually [4]. Formulations of silver nitrate have been therapeutically well-known since the 18th century [9] Many of these inorganic forms rapidly lose effectiveness since the silver cations are released rapidly at the infection site [10]. Scarce literatures evaluated the potential effect of less adverse effect of silver salts on broiler performance, or potential in vivo efficacy through a course of a disease using chicken as a model animal
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