Abstract
Abstract Background The recent SARS-CoV-2 pandemic posed a significant threat to human life. Vaccines played an unprecedented role in managing adverse outcomes, but the virus's ability to mutate and produce new variants posed ongoing challenges. This research aimed to examine the association between different types and numbers of doses of COVID-19 vaccinations and the clinical and demographic characteristics of patients. Methods This retrospective cross-sectional study was carried out on 161 COVID-19 patients hospitalized at Afzalipour Hospital in Kerman, Iran, during the eighth wave of the pandemic. Data on demographic features, symptoms, patient status, disease outcome, and vaccination history of patients were collected. Results Most patients (over 75%) had received 2 or 3 doses of the vaccine. Vaccination type and the number of doses showed significant differences based on patient gender (P = 0.048) and age group (P = 0.034), respectively. Shortness of breath showed significant differences based on the type of vaccine received (P = 0.0178). Fatigue substantially differed based on the number of vaccine doses (P = 0.03975). There were no significant differences in gastrointestinal symptoms, patient or disease status based on the number or type of vaccines, but lower death rates were observed in vaccinated patients. Additionally, while trends indicated better outcomes with a higher number of vaccine doses, there were no significant variations in blood oxygen saturation (SpO2) or respiratory rate based on the type or number of vaccine doses. Conclusions The findings highlight the role of vaccination in managing COVID-19 outcomes despite the reduction of vaccine efficacy against emerging variants.
Published Version
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