Abstract
Abstract Microalbuminuria, an early marker of renal injury, may begin early in sickle cell disease (SCD). We conducted a retrospective chart review of 205 patients with SCD. Clinical data and treatment regimens were reviewed. Data were analyzed to determine prevalence and correlates of microalbuminuria and proteinuria. Thirty-one patients (15.2%) had microalbuminuria. Proteinuria, hematuria, age, height, weight, and systolic blood pressure were significantly associated with microalbuminuria. Age was the strongest predictor. We propose that all children with SCD be screened by annual urinalysis and careful blood pressure monitoring at each clinic visit for early identification of children at risk for renal injury.
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