Abstract
ObjectivesTo determine the incidence of trisomy 21 in our population and the prenatal detection rate of maternal age as the screening method. Material and methodsWe performed an observational, longitudinal, retrospective study from January 1st 1995 to December 31st 2002. ResultsThe overall incidence of trisomy 21 in our population was 2.09/1000 newborns. One of every three cases of trisomy 21 was detected in women aged less than 35 years. Maternal age as a screening test had a detection rate for trisomy 21 of 45.66%. Postnatal diagnosis of Down syndrome was made mainly in women aged less than 35 years (58.18%). Of these, only 13.51% of had a prenatal diagnosis of trisomy 21. ConclusionsScreening for trisomy 21 is insufficient in our population. A sequential screening program, based on maternal age, nuchal translucency and maternal serum biochemical tests between weeks 11 and 14, should be performed.
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