Abstract

Estrogen and Susceptibility of Alzheimer’s Disease

Highlights

  • Alzheimer’s disease (AD) is the most common form of dementia, accounting for 50-60%, and is a typical progressive neurodegenerative disease [1,2]

  • AD is characterized by a number of pathological features, notably extracellular senile plaques formed by the aggregation of Abeta amyloid protein (Aβ) and the neurofibrillary tangles (NFTs) in the neuronal cells formed by hyperphosphorylation Tau protein, accompanied by important pathological changes such as brain neuron death, synaptic loss and reactive gliosis [3]

  • Estrogen plays an important role in the repair of more than one disease, including angiocardiopathy [18,29], osteoporosis [30], spondyloarthritis [31], brest cancer [32], AD and Parkinson disease [33,34]

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Summary

Review Article

Curr Trends Biomedical Eng & Biosci Copyright © All rights are reserved by Jingshan Shi Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, China Submission: December 11, 2019; Published: December 16, 2019 *Corresponding author: Jingshan Shi, Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi Guizhou, China

Introduction
Endogenous Estrogen Synthesis
Physiological Function of Estrogen
Estrogen Receptors
Estrogen Receptors in CNS
Estrogen disorder and AD
Findings
Estrogen Receptors and AD
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