Abstract
Ficus glomerata is commonly used for the treatment of diabetes. We planned to isolate compound from the ethanol extract of F. glomerata bark, and also evaluate the antidiabetic activity of isolated fractions in Streptozotocin (STZ)-induced diabetic rats. Oral administration of ethanol extract of bark and root of F. glomerata at the doses of 200 and 400 mg/kg body weight was studied in STZ-induced diabetic rats. After administration of extract the fasting blood glucose levels were significantly decreased. The eight different fractions were collected from ethanol extract of F. glomerata bark and dried. The fraction F4, F5, F6, F7 and F9 were administered orally in Streptozotocin (STZ)-induced diabetic rats. After the administration of fractions, blood glucose levels were monitored at specific intervals and it was found that they were significant lowered. The effect of fractions on induced hyperlipidemia was analyzed where the fraction significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the High density lipoprotein (HDL). Glibenclamide was used as a standard drug at a dose of 0.50 mg/kg body weight. Moreover, the fraction treated rats exhibited the significant rise in serum insulin level compared with streptozotocin- induced diabetic rats. The findings demonstrated that fraction isolated from ethanol extracts of F. glomerata bark has significant antidiabetic activity in streptozotocin-induced rats compared to standard drug. These results indicated that F. glomerata possesses significant antidiabetic and antihyperlipidemic effect due to presence of these fractions.
Highlights
Every year the number of diabetic patients is growing alarmingly all over the World
In our earlier study we reported that ethanol extract of bark extract of F. glomerata exhibited maximum significant antidiabetic activity compared to root extract
The phytochemical investigation of ethanol extracts of Ficus glomerata bark revealed the presence of alkaloids, Saponins, glycosides, carbohydrates, tannins & phenolic compounds and flavonoids
Summary
Every year the number of diabetic patients is growing alarmingly all over the World. Most of the hypoglycemic agents used in allopathic medicines are reported to have side effects in the long run. There is a need to search for effective and safe drugs for diabetes[1]. The use of herbal medicines for the treatment of diabetes mellitus has gained importance throughout the world. The World Health Organization has recommended and encouraged this practice, especially in countries where access to the conventional treatment of diabetes is not adequate. There is an increased demand for using natural products with antidiabetic activity, on account of the side effects associated with the use of insulin and oral hypoglycemic agents. The available literature shows that there are more than 400 plant species showing hypoglycemic activity[2]
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