Evaluation of Antidiabetic Activity of Isolated Compound from Ougeinia oojeinensis Bark Extract in Diabetic Rats

Abstract

Ougeinia oojeinensis is used by tribal people for treatment of diabetes. The present aim of this study was to isolate different fractions from O. oojeinensis bark extracts, and evaluated the potency of antdiabetic activity of fractions. The nine different fractions were collected from ethanol extracts of O. oojeinensis bark. The fraction F4, F6, F7 and F8 were administered orally in Streptozotocin (STZ)-induced diabetic rats. After the administration of fractions, blood glucose levels were monitored at specific intervals and it was found that they were significant lowered. The effect of fractions on induced hyperlipidemia was analyzed where the fraction significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the High density lipoprotein (HDL). Glibenclamide was used as a standard drug at a dose of 0.50 mg/kg body weight. Moreover, the fraction treated rats exhibited the significant rise in serum insulin level compared with streptozotocin- induced diabetic rats. The findings demonstrated that fraction isolated from ethanol extracts of O. oojeinensis bark has significant antidiabetic activity in streptozotocin-induced rats compared to standard drug.