Abstract
Oral squamous cell carcinoma (OSCC) is one of the life threatening and mutilating disease affecting the mankind. Most invasive OSCC are preceded by clinical premalignant lesions and conditions such as oral leukoplakia, erythroplakia, oral lichen planus, and oral submucous fibrosis (OSMF). These remain in preinvasive stage for years and the cancerous alterations remain indolent and not readily recognizable on clinical and histopathologic examination. There are various biological markers which can be used to monitor progression of precancerous lesions to cancer, predict the therapeutic response and prognostic outcome of cancer. Among these serum alkaline phosphates (ALP) is recognized as an important marker of induction of tumor cell differentiation. We attempt to analyze the role of these enzymes as a biomarker in OSCC cases.
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