Abstract
Recent studies suggest that androgens are the main regulator of changes in human hair growth, and dermal papilla (DP) is known to secret factors which regulate the growth and activity of the cells in the follicle in response to androgens. However, published data of androgen-regulated genes in human dermal papilla cells is limited and genome-wide large scale screening has not been reported. To identify the dihydrotestosterone (DHT)-regulated genes in human dermal papilla cells. SV40T-transformed human dermal papilla cell line (SV40T-DPC) was established and DHT-regulated genes were screened by cDNA microarray analysis. SV40T-DPC maintained early passage morphology and expressed functional androgen receptors. cDNA microarray followed by RT-PCR analysis showed that a number of genes are regulated by DHT in SV40T-DPC. The DHT-regulated genes reported in this study may be involved in androgen-mediated regulation of hair growth.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
