Abstract
Autonomic diabetic neuropathy (ADN) is a complication of diabetes mellitus (DM), to which there is no specific treatment. In this study, the efficacy of the essential oil of Croton zehntneri (EOCz) in preventing ADN was evaluated in the rat vagus nerve. For the two fastest conducting myelinated types of axons of the vagus nerve, the conduction velocities and rheobase decreased, whilst the duration of the components of the compound action potential of these fibers increased. EOCz completely prevented these DM-induced alterations of the vagus nerve. Unmyelinated fibers were not affected. In conclusion, this investigation demonstrated that EOCz is a potential therapeutic agent for the treatment of ADN.
Highlights
Diabetes mellitus (DM) is a chronic disease that frequently damages the nerves resulting in diabetic neuropathy (DN), which is the most debilitating and prevalent diabetic complication
DN can affect the nerves of the autonomic nervous system causing autonomic diabetic neuropathy (ADN) that is manifested by the dysfunction of one or more organic systems, the cardiovascular and gastrointestinal systems being the most frequently affected
essential oil of Croton zehntenri (EOCz) has low toxicity documented in sub-chronic administration and in acute studies, a property which increases the potentiality of this essential oil for use in DN therapy [22,27]
Summary
Diabetes mellitus (DM) is a chronic disease that frequently damages the nerves resulting in diabetic neuropathy (DN), which is the most debilitating and prevalent diabetic complication. DN can affect the nerves of the autonomic nervous system causing autonomic diabetic neuropathy (ADN) that is manifested by the dysfunction of one or more organic systems, the cardiovascular and gastrointestinal systems being the most frequently affected. It is a serious and relatively prevalent complication that is associated with an increased risk of cardiovascular mortality, and with multiple symptoms and damage to the quality of life of diabetic patients [8,9,10]. EOCz has low toxicity documented in sub-chronic administration (dosed 1–300 mg/kg, p.o.) and in acute studies (its LD50 was 3.5 g/kg, oral route), a property which increases the potentiality of this essential oil for use in DN therapy [22,27]
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