Abstract
BackgroundHuman papillomavirus (HPV) infection is the main etiological factor for the development of cervical cancer. Here we assessed the prevalence and distribution of HPV genotypes in Fujian population.MethodsA total of 8678 women aging from 17 to 84 years olds were recruited from the Fujian Medical University Union Hospital in Fujian Province. Every woman had a face-to-face interview. Cervical samples were collected from each participant and HPV screening was conducted using microarray hybridization.ResultsOur study showed that the HPV prevalence in Fujian province was 38.3%. Among the positive individuals, 70.6% were detected for single HPV infection, 29.4% for multiple HPV infections. Further analysis showed that the prevalence of HPV infection significantly increased from 2009 to 2015. The four most common high risk human papillomavirus (HR-HPV) genotypes were HPV16 (8.5%), HPV52 (7.9%), HPV58 (6.2%), HPV 53 (3.5%), collectively accounting for 60.5% of all detected HPV infection. Age subgroup analysis showed two peaks for the frequencies of overall and multiple HPV infections, one for the group of women under 25 years old, and the other for the group over 55 years old.ConclusionsHPV infection is becoming serious in Fujian province, which indicates the imperative to implement a HPV vaccination and screening program for this region.
Highlights
Human papillomavirus (HPV) infection is the main etiological factor for the development of cervical cancer
Single HPV infection accounted for 27.1% (2351/8678) of all the participants and 70.6% (2351/3328) of positive samples, and further analysis showed that, among women with single HPV infection, single high risk human papillomavirus (HR-HPV) infection accounted for 59.5% (1982/3328), while single Low risk human papillomavirus (LR-HPV) accounted for 11.1% (369/3328)
Time trends in prevalence of HPV infection We analyzed the prevalence of HPV infection in Fujian province from 2009 to 2015 and found that the prevalence of HPV infection significantly increased, ranging from 29.4% in 2009 to 43.4% in 2015 (Table 1)
Summary
Human papillomavirus (HPV) infection is the main etiological factor for the development of cervical cancer. The relationship between cervical cancer and human papillomavirus (HPV) infection is widely studied, and it has been approved that HPV infection plays an important role in the development of cervical cancer during past decades [3, 4], so it is necessary for the cervical cancer prevention to detect timely, prevent and decrease HPV infection. More than 100 HPV genotypes have been identified and about 40 genotypes can infect the genital tract [5]. According to their associations with cervical cancer and precancerous lesions, HPV genotypes are Nowadays, vaccine is crucial in the prevention of HPV infection and cervical cancer. Three licensed HPV vaccines have been implementation in most western
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